![]() ![]() ![]() We evaluated gut barrier function spectrophotometrically using fluorescein isothiocyanate (FITC)-labelled dextran. Methods: C57BL/6J mice and Caco-2 cell line were treated. However, whether and how melatonin alleviates CIH-induced intestinal barrier dysfunction remains unclear. Increasing evidence suggests therapeutic effects of melatonin on systemic inflammation and gut microbiota remodelling. work is licensed under a CC BY 4.0 LicenseStatus:PostedVersion 1posted 24 Mar, 2023You are reading this latest preprint versionAbstractBackground: Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Melatonin Alleviates Chronic Intermittent Hypoxia-induced Microbiota Dysbiosis and Attenuates Intestinal Barrier Dysfunction via STAT3/Th17 signalling pathway | Research Square BrowsePreprintsCOVID-19 PreprintsProtocolsVideosJournalsTools & ServicesOverviewDigital EditingProfessional EditingBadgesResearch PromotionYour CartAboutPreprint PlatformIn ReviewEditorial PoliciesOur TeamAdvisory BoardBlogHelp CenterSign InSubmit a PreprintCiteShareDownload PDFResearchMelatonin Alleviates Chronic Intermittent Hypoxia-induced Microbiota Dysbiosis and Attenuates Intestinal Barrier Dysfunction via STAT3/Th17 signalling pathwayHuajun Xu, Fan Wang, Zhenfei Gao, Weijun Huang, Xiaoman Zhang, and 6 moreThis is a preprint it has not been peer reviewed by a journal. ![]()
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